Examining metabolic demand in high density CHO cell cultures.


High density cell culture systems offer the advantage of production of biopharmaceuticals in compact bioreactors with high volumetric production rates. However, Chinese hamster ovary (CHO) cells must be engineered to achieve maximum performance under the culture condition of choice. Cell line optimization requires a deep understanding of the cell metabolism as well as the development of bioprocess strategies to maximize cell performance. Here, our major interest is to investigate CHO cells during perfusion under different treatments to maximize its metabolic performance, stability and product yield.

Lead investigator Dr Cristiana Dal’Molin
Associate investigator Dr Esteban Marcellin
Postdoc Dr Veronica S Martinez
PhD Student Matthias Nöbel
Industry Partner Patheon. PI: Shave.