Development of continuous downstream processing strategies incorporating continuous chromatography


This project will develop and evaluate a periodic counter current (PCC) chromatography and straight-through processing (STP) continuous three-step mAb purification process. Process intensification by implementing continuous or semi-continuous downstream processes in mAb production, for example, can contribute to significant cost-savings and improved throughput. Continuous processing also offers the possibility of increased automation of the process. The project will develop these bioprocesses using model proteins, thereby developing a new, innovative bioprocess platform for the large scale production of mAbs.

 

Lead investigator Associate Professor Linda Lua
Postdoc Dr Gary Shooter
PhD Student Kristina Pleitt
Industry Partner Collaborative project with GE and Patheon.