This project will develop and evaluate a periodic counter current (PCC) chromatography and straight-through processing (STP) continuous three-step mAb purification process. Process intensification by implementing continuous or semi-continuous downstream processes in mAb production, for example, can contribute to significant cost-savings and improved throughput. Continuous processing also offers the possibility of increased automation of the process. The project will develop these bioprocesses using model proteins, thereby developing a new, innovative bioprocess platform for the large scale production of mAbs.